Kristel Sleegers Selected Research

Frontotemporal Dementia (Semantic Dementia)

1/2018	Common and rare TBK1 variants in early-onset Alzheimer disease in a European cohort.
1/2018	Clinical variability and onset age modifiers in an extended Belgian GRN founder family.
1/2017	TBK1 Mutation Spectrum in an Extended European Patient Cohort with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis.
8/2009	Neuronal inclusion protein TDP-43 has no primary genetic role in FTD and ALS.
4/2007	Mutations other than null mutations producing a pathogenic loss of progranulin in frontotemporal dementia.

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Kristel Sleegers Research Topics

Disease

65	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 06/2002
16	Dementia (Dementias) 01/2022 - 02/2010
12	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 01/2020 - 10/2007
9	Cognitive Dysfunction 01/2022 - 02/2010
5	Frontotemporal Dementia (Semantic Dementia) 01/2018 - 04/2007
4	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020 - 08/2009
4	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2018 - 08/2009
3	Genetic Risk Score 01/2021 - 12/2015
2	Amyloid Plaque 01/2013 - 10/2009
2	Atrophy 01/2012 - 01/2011
2	Bipolar Disorder (Manic Depressive Psychosis) 10/2006 - 10/2006
1	Inflammation (Inflammations) 01/2022
1	Tauopathies 01/2020
1	Chromosome Inversion (Chromosomal Inversion) 01/2019
1	Memory Disorders (Memory Loss) 01/2018
1	Type 2 Diabetes Mellitus (MODY) 01/2016
1	Cerebrovascular Disorders (Cerebrovascular Occlusion) 01/2016
1	Disease Susceptibility (Diathesis) 09/2014
1	Peripheral Nervous System Diseases (PNS Diseases) 08/2014
1	Dopa-responsive Dystonia 09/2012
1	Cardiovascular Diseases (Cardiovascular Disease) 02/2012
1	Disease Progression 09/2007
1	Mental Disorders (Mental Disorder) 10/2006

Drug/Important Bio-Agent (IBA)

26	Biomarkers (Surrogate Marker)IBA 01/2022 - 09/2007
20	Amyloid (Amyloid Fibrils)IBA 01/2022 - 06/2002
15	Apolipoproteins E (ApoE)IBA 01/2022 - 08/2005
13	Proteins (Proteins, Gene)FDA Link 01/2021 - 06/2002
9	ApolipoproteinsIBA 01/2022 - 08/2005
9	ProgranulinsIBA 03/2016 - 04/2007
7	Amyloid beta-PeptidesIBA 01/2022 - 06/2006
5	Peptides (Polypeptides)IBA 11/2020 - 09/2007
4	UbiquitinIBA 02/2011 - 04/2007
3	DNA (Deoxyribonucleic Acid)IBA 10/2021 - 01/2010
3	Blood Proteins (Serum Proteins)IBA 01/2021 - 11/2019
3	Adenosine Triphosphate (ATP)IBA 01/2019 - 09/2017
3	Carrier Proteins (Binding Protein)IBA 01/2019 - 02/2009
3	Nonsense Codon (Nonsense Mutation)IBA 01/2018 - 03/2016
3	sortilinIBA 01/2016 - 01/2009
3	DNA-Binding Proteins (DNA Binding Protein)IBA 03/2011 - 08/2009
2	NeurograninIBA 10/2021 - 12/2015
2	PresenilinsIBA 11/2020 - 06/2002
2	LipidsIBA 09/2019 - 01/2019
2	Phosphotransferases (Kinase)IBA 01/2018 - 01/2017
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 03/2016 - 12/2010
2	EnzymesIBA 12/2015 - 08/2009
2	ClusterinIBA 07/2015 - 01/2012
2	Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)IBA 01/2013 - 10/2006
2	Tryptophan HydroxylaseIBA 01/2013 - 10/2006
2	Neurotransmitter Agents (Neurotransmitter)IBA 01/2013 - 10/2006
2	Biological ProductsIBA 10/2009 - 08/2005
2	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 08/2005 - 08/2005
1	Dithionitrobenzoic Acid (Ellman's Reagent)IBA 01/2022
1	7- (6- fluoropyridin- 3- yl)- 5H- pyrido(4,3- b)indoleIBA 01/2022
1	Chitinase-3-Like Protein 1IBA 10/2021
1	sharpinIBA 01/2021
1	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2020
1	Dipeptidyl-Peptidases and Tripeptidyl-PeptidasesIBA 01/2019
1	AmidesIBA 01/2019
1	GranulinsIBA 01/2018
1	Small Interfering RNA (siRNA)IBA 01/2018
1	florbetapirIBA 01/2017
1	Cysteine (L-Cysteine)FDA Link 03/2016
1	Myeloblastin (Proteinase 3)IBA 03/2016
1	Amino Acids FDA Link 03/2016
1	Leukocyte Elastase (Neutrophil Elastase)IBA 03/2016
1	Pharmaceutical PreparationsIBA 12/2015
1	Phospholipases (Phospholipase)IBA 12/2015
1	NucleotidesIBA 12/2015
1	ImmunosorbentsIBA 12/2015
1	Protein Isoforms (Isoforms)IBA 01/2015
1	Ligases (Synthetase)IBA 08/2014
1	Transfer RNA (tRNA)IBA 08/2014
1	Complement Receptors (Complement Receptor)IBA 09/2013
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2013
1	Guanosine Triphosphate (GTP)IBA 09/2012
1	3' Untranslated Regions (3' UTR)IBA 04/2011
1	Vacuolar Proton-Translocating ATPases (V-Type ATPase)IBA 02/2011
1	Indicators and Reagents (Reagents)IBA 02/2011
1	Dynamins (Dynamin)IBA 12/2009
1	MicroRNAs (MicroRNA)IBA 08/2009
1	CalciumIBA 04/2009
1	Threonine (L-Threonine)FDA Link 09/2007
1	tau Proteins (tau Protein)IBA 09/2007
1	amyloid beta-protein (1-42)IBA 09/2007
1	CholesterolIBA 08/2007
1	Catechol O-Methyltransferase (Methyltransferase, Catechol)IBA 10/2006
1	Dopamine D3 ReceptorsIBA 10/2006
1	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 06/2002

Therapy/Procedure

1	Secondary Prevention 11/2019